Senior Scientist / Associate Director, T Cell Immunology
Basecamp Research is an AI-biology company building the BaseData genomic dataset and EDEN biological foundation models for therapeutic design.
About Basecamp Research
The company uses proprietary evolutionary sequence data to train EDEN foundation models, including models that can be accessed through Claude for antibiotic-peptide design and immunogenicity prediction. Its therapeutic platform also includes AI-Programmable Gene Insertion (aiPGI).
Skills
Candidate Availability
Required and preferred rules are kept separate and reflect the wording in the original posting.
About the Role
You will own T cell immunology strategy for oncology and autoimmunity cell-therapy programs. You will design, run, and interpret primary human T-cell assays; characterize gene-editing enzymes; and define candidate-selection criteria. You will lead in vivo mouse and NHP studies with CRO partners, direct pharmacology and safety work for IND-enabling studies, contribute to regulatory filings and agency interactions, and mentor scientists while building a small team.
Requirements
- PhD in immunology, molecular biology, bioengineering, or a related life-sciences field with substantial cell or gene therapy industry experience, or an MSc with equivalent hands-on experience
- 6+ years post-PhD experience for Senior Scientist or 9+ years for Associate Director
- Expertise in primary human T cell isolation, activation, expansion, transfection, transduction, and functional characterization
- Experience with gene editing in primary immune cells and measuring editing outcomes
- Expertise in multiparameter flow cytometry, including panel design and analysis
- Fluency with ddPCR, qPCR, NGS library preparation, QC, and on/off-target analytics
- Experience designing and overseeing in vivo mouse studies, including CRO management
- Excellent communication skills with internal and external stakeholders
Responsibilities
- Own T cell immunology strategy across oncology and autoimmunity programs
- Translate program goals into assay and study plans
- Lead mouse and NHP studies for PK/PD, biodistribution, persistence, and immunogenicity with CRO partners
- Drive pharmacology and safety components of IND-enabling work, including toxicology study design and CRO oversight
- Assess biodistribution and insertional mutagenesis and author regulatory filing sections
- Represent data in pre-IND and agency interactions, partner meetings, and internal governance
- Design, run, and interpret in vitro potency and specificity assays in primary human T cells and cell lines
- Mentor scientists and grow the team
Benefits
- Equity
- Healthcare
- Carrot Fertility with IVF stipend
- 401(k)
- Life insurance