Senior Director Disease Biology
Independent nonprofit research institute building AI-and-biology tools and conducting biomedical research on complex diseases.
About Arc Institute
Arc Institute is a Palo Alto-based independent nonprofit founded in 2021. It supports long-term biomedical research and develops experimental, computational, and machine-learning technologies, including virtual-cell and genomic foundation models, in partnership with Stanford University, UC Berkeley, and UCSF.
Skills
Candidate Availability
Required and preferred rules are kept separate and reflect the wording in the original posting.
About the Role
You will build and lead a team that advances validated targets through drug discovery and preclinical programs. You will direct target discovery and ADI model teams, prioritize candidates, apply causal modeling and human genetics, manage external partners, and represent discovery strategy in portfolio discussions.
Requirements
- PhD in neuroscience, immunology, cell biology, genetics, pharmacology, or a related field
- Extensive neurodegeneration target-discovery leadership experience
- Experience advancing programs through lead optimization and IND-enabling studies
- Advanced 3D neurodegenerative disease cellular-model expertise
- People leadership and cross-functional program leadership
- Causal modeling and human genetic data experience
- Ability to work onsite at least four days per week
Responsibilities
- Build a target discovery and preclinical development team
- Guide programs through lead optimization and in vivo proof of concept
- Lead target discovery and validation
- Lead in vivo and in vitro discovery teams
- Apply causal modeling and human genetic data to prioritize targets
- Align priorities across discovery and preclinical programs
- Manage CRO and external partner relationships
- Represent discovery strategy in portfolio discussions
Benefits
- Annual discretionary bonus