Research Lead Senior Scientist DMPK
Isomorphic LabsVisit Isomorphic Labs website
AI-first drug design and development company building a unified drug-design engine to advance new medicines.
Series BRecently funded
London, United Kingdom
Funding history
Investors
About Isomorphic Labs
Isomorphic Labs uses predictive and generative AI models, computational biology, and drug-design expertise to develop therapeutics across partnered and internal programs.
Skills
Candidate Availability
Required and preferred rules are kept separate and reflect the wording in the original posting.
About the Role
You will design and implement AI-first DMPK strategies for drug discovery projects. You will build screening cascades and mechanistic experiments, integrate DMPK, pharmacology, and toxicology data, optimize molecule design, develop quantitative pharmacology strategies, and author regulatory documentation.
Requirements
- PhD in pharmaceutical science, pharmacy, chemistry, or a relevant subject
- 8+ years of professional experience as a DMPK Lead in drug discovery
- Experience supporting DMPK across multiple modalities
- Understanding of drug metabolism, pharmacokinetics, PKPD principles, and translational research
- Experience developing DMPK and quantitative pharmacology packages for early clinical development
- Experience authoring and reviewing regulatory documents
- Experience partnering with preclinical and clinical teams
- Cross-functional leadership, communication, and collaborative problem-solving skills
- Knowledge of biotransformation
- Experience applying NAMs
- Knowledge of PKPD modelling
- Understanding of machine learning techniques
- Familiarity with R, Python, and KNIME
Responsibilities
- Design and implement stage-appropriate AI-first DMPK strategies
- Design screening cascades and mechanistic experiments
- Integrate DMPK, pharmacology, and toxicological data to inform decisions
- Define quantitative pharmacology strategies with Pharmacology Leads
- Optimize datasets to address DMPK questions
- Optimize molecule design with Chemistry Leads using physicochemistry and biotransformation knowledge
- Maintain knowledge of technologies and methods for human PK prediction
- Author DMPK sections of regulatory documents
- Champion inclusion and continuous professional development