Scientist / Senior Scientist Peptide Discovery
Basecamp Research is an AI-biology company building the BaseData genomic dataset and EDEN biological foundation models for therapeutic design.
About Basecamp Research
The company uses proprietary evolutionary sequence data to train EDEN foundation models, including models that can be accessed through Claude for antibiotic-peptide design and immunogenicity prediction. Its therapeutic platform also includes AI-Programmable Gene Insertion (aiPGI).
Skills
Candidate Availability
Required and preferred rules are kept separate and reflect the wording in the original posting.
About the Role
You will validate peptide candidates using mammalian cell culture and cell-based functional, safety, and developability assays. You will run cytotoxicity, hemolysis, permeability, immunogenicity, and receptor-activation assays; analyze dose responses; maintain laboratory documentation; and share results with computational and AI colleagues to guide peptide selection.
Requirements
- PhD in a relevant life-sciences field or an MSc with equivalent hands-on laboratory experience
- Hands-on mammalian cell culture experience
- Flow cytometry expertise using antibody panels and fluorescent reporters
- Experience with cell-based functional and signaling assays
- Ability to independently manage multi-step, multi-day assays
- Experience with hemolysis or peptide membrane-toxicity assays
- Knowledge of proteolytic and serum stability assays
- Experience with permeability or barrier models
- Experience with immunogenicity risk-assessment tools, epitope prediction software, or PBMC-based assays
Responsibilities
- Perform mammalian cell culture
- Design and execute cell-based cytotoxicity and viability assays
- Run hemolysis assays for peptide candidates
- Run cell permeability assays
- Support immunogenicity risk assessment using in silico and PBMC-based approaches
- Run GLP-1R and related incretin receptor activation assays
- Support establishment of stable reporter and receptor cell lines
- Generate and fit dose-response curves for potency and safety endpoints
- Prepare peptide stock and working solutions
- Support fungal susceptibility assays
- Maintain detailed laboratory notebooks and contribute to reports and figures
- Relay experimental results to computational and AI colleagues
- Design cell-based assay strategies and propose follow-on testing
- Mentor junior staff and set assay-development priorities at Senior Scientist level
Benefits
- Equity
- Healthcare
- Carrot Fertility with IVF stipend
- 401(k)
- Life insurance