Research Leader or Senior Scientist in In Vivo Pharmacology and Translational Sciences
Isomorphic LabsVisit Isomorphic Labs website
AI-first drug design and development company building a unified drug-design engine to advance new medicines.
London, United Kingdom
Funding history
Investors
About Isomorphic Labs
Isomorphic Labs uses predictive and generative AI models, computational biology, and drug-design expertise to develop therapeutics across partnered and internal programs.
Skills
Candidate Availability
Required and preferred rules are kept separate and reflect the wording in the original posting.
About the Role
You will establish translational strategies, plan in vitro and in vivo pharmacology, PK/PD, and safety assessments, and select appropriate model paradigms. You will oversee CRO studies, develop biomarker strategies, interpret data for go or no-go decisions, and support clinical trial design. Some positions include people management.
Requirements
- PhD in Pharmacology, Immunology, Cancer Biology, Molecular Biology, or a related scientific discipline
- 5+ or 8+ years of Translational Sciences experience in biotech, pharma, or a CRO
- Drug-discovery project leadership experience
- Expert knowledge of translational models in oncology or immune disorders
- Experience developing Target Product Profiles and screening cascades
- Experience constructing translational data packages and biomarker strategies
- Experience designing PK/PD experiments for human dose prediction
- Experience managing multi-vendor CRO networks
- Project management and matrix leadership skills
Responsibilities
- Oversee planning and implementation of in vitro and in vivo pharmacology, PK/PD, and safety assessments
- Design translational strategies for clinical translation and patient selection
- Define model paradigms and biomarker strategies
- Work with CROs to design experiments and deliver biological data
- Provide scientific expertise to machine learning and computational biology teams
- Distill biological data into insights and recommendations
- Lead or contribute strategic input to project delivery
- Analyze experimental data and prepare reports supporting go or no-go decisions and IND filings
- Translate computational predictions into physical validation protocols
- Align preclinical efficacy with ADME, exposure, safety, and clinical-development plans
- Line manage and mentor In Vivo Pharmacologists when applicable