Scientist - Ensemble Structural Informatics
A 501(c)(3) science-and-technology research institute/foundation operating direct Neuro-AI research, life-sciences programs through Radial, and an open-science residency program.
About Astera Institute
Astera Institute supports and operates open public-goods work for science and technology. Its current activities include neuroscience-informed AGI research, AI-enabled life-sciences programs, open datasets and publishing infrastructure, and residencies for early-stage projects.
Skills
Candidate Availability
Required and preferred rules are kept separate and reflect the wording in the original posting.
About the Role
You will develop ensemble-aware validation standards and foundational infrastructure for dynamic structural biology data. You will define validation metrics and forward models across crystallography, cryo-EM, and related techniques; guide data deposition, search, and retrieval tools; and translate scientific requirements into robust technical solutions with technical stakeholders.
Requirements
- Ph.D. in structural biology, biophysics, computational biology, or a related field
- Demonstrated expertise in structural biology methods
- Deep understanding of structural heterogeneity and dynamics in biomolecular systems
- Experience with data standards, metadata frameworks, or scientific database development
- Collaborative skills and ability to build consensus across diverse scientific communities
Responsibilities
- Oversee development of ensemble-aware validation frameworks assessing fit-to-data, physical realism, and uncertainty across structural representations
- Identify and prioritize technical challenges in data representation and validation frameworks
- Guide creation of data deposition, search, and retrieval tools for structural heterogeneity
- Coordinate with stakeholders to ensure interoperability and adoption
- Translate scientific requirements into robust technical solutions with software developers, data engineers, and user experience designers